John Cox Hupp (1819-1908) was a prominent physician in Wheeling, West Virginia. He held positions as physician to the Ohio County almshouse and jail, U.S. District Court, City Board of Health, and Children’s Home. He served as a delegate for the American Medical Association to European medical associations and on the executive committee of the Centennial Medical Commission's International Medical Congress. As a founder of West Virginia’s Medical Society, Hupp introduced chloral hydrate as an anesthetic. He advanced public health reforms and became a longtime U.S. pension examining surgeon. In education, Hupp extended free public schools to African American children and introduced German language and industrial arts instruction. He served in local government on the Board of Health, as County Board of Supervisors president, and the Board of Education. In 1853 Hupp married Carolene Louisa Todd, with whom he had three sons and three daughters. When he died in 1908 at age 88, he was buried in Greenwood Cemetery in Wheeling. His legacy was as a leader in medicine and progressive reforms in 19th century Wheeling.
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